Perilipin 2 — another piece in the big jigsaw puzzle of coronary no reflow

Vascular smooth muscle cell microparticles and coronary no-reflow: another piece of the puzzle?

Thromb Haemost 2005; 94: 693–4 Coronary no-reflow is a rare but potentially devastating complication that can occur during percutaneous coronary interventions (PCI). It is defined as the lack of passage of contrast dye into the microvasculature despite relief of the original obstruction in the epicardial vessel and is an angiographic marker of impaired myocardial perfusion at the tissue level (...

Capturing VCP: Another Molecular Piece in the ALS Jigsaw Puzzle

TDP-43 mislocalization and aggregation are implicated in the pathogenesis of ALS and FTLD-U. Valosin containing protein (VCP) mutations also lead to TDP-43 deposition, resulting in Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD). In this issue of Neuron, Johnson et al. used whole-exome capture to identify VCP mutations in familial ALS. This extends the VCP phenotype...

Another piece in the puzzle

Pulmonary ischemia-reperfusion injury is complex and involves many cell types and mechanisms of action. Van Putte and coworkers have attempted to provide insight into and describe some of the complex components of this process. Their study describes two new components of the multifaceted process of reperfusion injury. The time-dependent course of neutrophil activation and the discovery of progr...

Preshock phase singularity and defibrillation outcome: another piece to solve the jigsaw puzzle?

Another piece of the meiosis puzzle

M the process by which the ovary and testis produce haploid gametes from initially diploid cells, is essential for sexual reproduction in mammals. This process, initially described in the late 19th and early 20th century using model organisms such as sea urchins, worms and fruit flies, continues to attract extensive interest from reproductive biologists due to its centrality in gametogenesis. T...